Sikeston Hotels, Resorts, and Rentals

Compare HOTELS, RESORTS, AND RENTALS in Sikeston, Missouri, USA

Drury Inn & Suites Jackson MO
FromAU $186 per night
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9.5 (346 Reviews)
26 Bedrooms 42 Guests
Rockwood Inn
FromAU $236 per night
10.0 (20 Reviews)
1 Bedroom 2 Guests
Drury Plaza Hotel Cape Girardeau Conference Center
|
9.4 (646 Reviews)
238 Bedrooms 90 Guests
Hampton Inn By Hilton Dexter
FromAU $154 per night
10.0 (10 Reviews)
1 Bedroom 2 Guests
Drury Inn & Suites Cape Girardeau
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9.4 (531 Reviews)
85 Bedrooms 30 Guests
Drury Plaza Hotel Cape Girardeau Conference Center
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9.6 (1007 Reviews)
1 Bedroom 2 Guests
Tru By Hilton Cape Girardeau
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9.4 (84 Reviews)
89 Bedrooms 18 Guests
Drury Inn & Suites Sikeston, MO
FromAU $179 per night
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9.6 (1006 Reviews)
1 Bedroom 2 Guests
The Riverview
FromAU $220 per night
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9.4 (11 Reviews)
60 Bedrooms 12 Guests
Drury Inn & Suites Jackson MO
FromAU $119 per night
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9.6 (1005 Reviews)
1 Bedroom 2 Guests
Drury Inn & Suites Sikeston
FromAU $185 per night
|
9.3 (801 Reviews)
155 Bedrooms 48 Guests
Hampton Inn Cape Girardeau I 55 East
9.6 (814 Reviews)
1 Bedroom 2 Guests
Fairfield by Marriott Inn & Suites Cape Girardeau
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9.3 (165 Reviews)
103 Bedrooms 48 Guests
Courtyard by Marriott Cape Girardeau Downtown
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9.6 (507 Reviews)
1 Bedroom 2 Guests
Courtyard by Marriott Cape Girardeau Downtown
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9.2 (159 Reviews)
91 Bedrooms 29 Guests
Tru By Hilton Cape Girardeau
9.6 (109 Reviews)
1 Bedroom 2 Guests
Hampton Inn Cape Girardeau I-55 East, MO
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9.1 (206 Reviews)
84 Bedrooms 24 Guests
Drury Inn & Suites Cape Girardeau
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9.4 (1003 Reviews)
1 Bedroom 2 Guests
Hampton Inn By Hilton Dexter
FromAU $160 per night
|
9.1 (28 Reviews)
77 Bedrooms 22 Guests
Pear Tree Inn Cape Girardeau West
8.8 (666 Reviews)
79 Bedrooms 14 Guests
The Riverview
FromAU $193 per night
|
9.4 (558 Reviews)
1 Bedroom 2 Guests
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
8.7 (261 Reviews)
102 Bedrooms 30 Guests
Fairfield Inn & Suites by Marriott Cape Girardeau
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9.4 (167 Reviews)
1 Bedroom 2 Guests
Hampton Inn Sikeston
FromAU $146 per night
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8.6 (86 Reviews)
91 Bedrooms 26 Guests
TownePlace Suites by Marriott Sikeston
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9.4 (16 Reviews)
1 Bedroom 2 Guests
Holiday Inn Express and Suites Sikeston by IHG
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8.5 (114 Reviews)
100 Bedrooms 51 Guests
Fairfield Inn & Suites by Marriott Sikeston
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9.2 (57 Reviews)
1 Bedroom 2 Guests
La Quinta Inn & Suites by Wyndham Jackson-Cape Girardeau
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8.4 (458 Reviews)
80 Bedrooms 20 Guests
Pear Tree Inn Cape Girardeau West
9.0 (1003 Reviews)
1 Bedroom 2 Guests
Fairfield by Marriott Inn & Suites Sikeston
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8.4 (50 Reviews)
53 Bedrooms 30 Guests
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
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9.0 (765 Reviews)
1 Bedroom 2 Guests
TownePlace Suites by Marriott Sikeston
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8.3 (10 Reviews)
6 Bedrooms 24 Guests
Hampton Inn Sikeston
FromAU $161 per night
9.0 (562 Reviews)
1 Bedroom 2 Guests
Comfort Inn & Suites Sikeston I-55
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8.1 (204 Reviews)
64 Bedrooms 16 Guests
Holiday Inn Express & Suites Sikeston Southwest by IHG
8.6 (457 Reviews)
1 Bedroom 2 Guests
Travelodge by Wyndham Dexter
FromAU $160 per night
7.9 (44 Reviews)
6 Bedrooms 17 Guests
Best Western Plus Sikeston I-55
FromAU $131 per night
8.4 (1002 Reviews)
1 Bedroom 2 Guests
Travel Inn and Suites- Sikeston Miner I-55 exit-67
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7.6 (449 Reviews)
37 Bedrooms 26 Guests
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
8.4 (780 Reviews)
1 Bedroom 2 Guests
Best Western Plus Sikeston I-55
FromAU $133 per night
|
7.6 (295 Reviews)
37 Bedrooms 18 Guests
Comfort Inn & Suites Sikeston I-55
8.4 (291 Reviews)
1 Bedroom 2 Guests
Jackson Town House Inn
FromAU $177 per night
7.6 (45 Reviews)
3 Bedrooms 6 Guests
Comfort Suites Jackson-Cape Girardeau
8.2 (766 Reviews)
1 Bedroom 2 Guests
Days Inn and Suites by Wyndham Sikeston
7.1 (238 Reviews)
26 Bedrooms 18 Guests
Candlewood Suites Cape Girardeau by IHG
8.0 (936 Reviews)
1 Bedroom 2 Guests
Super 8 by Wyndham Sikeston/Miner Area
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7.0 (174 Reviews)
60 Bedrooms 21 Guests
Town House Inn
FromAU $133 per night
7.6 (442 Reviews)
1 Bedroom 2 Guests
SEMO Redhawks Campus Home with Hot Tub
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10.0 (4 Reviews)
2 Bedrooms 4 Guests
Super 8 by Wyndham Charleston/Sikeston East MO
6.6 (634 Reviews)
1 Bedroom 2 Guests
Relax in the country at Countryside Villas! - Villa A
10.0 (33 Reviews)
2 Bedrooms 4 Guests
Econo Lodge Dexter
FromAU $78 per night
6.2 (37 Reviews)
34 Bedrooms 8 Guests
Eagle Inn Charleston
FromAU $94 per night
6.6 (105 Reviews)
1 Bedroom 2 Guests
The Twisted Sassafras Treehouse
10.0 (32 Reviews)
1 Bedroom 2 Guests
Town House Inn Cape Giradreau
6.2 (224 Reviews)
1 Bedroom 2 Guests
OYO Hickory House Inn
FromAU $108 per night
5.6 (135 Reviews)
1 Bedroom 2 Guests
Pear Tree Inn Sikeston
FromAU $121 per night
9.4 (1005 Reviews)
1 Bedroom 2 Guests
Pear Tree Inn Cape Girardeau Near the Medical Center
9.0 (1004 Reviews)
1 Bedroom 2 Guests
Euro Style Tiny Home with Deck
New
2 Bedrooms 3 Guests
Auburn Place Hotel And Suites
8.8 (1005 Reviews)
1 Bedroom 2 Guests
River Town Retreat near SEMO
FromAU $106 per night
9.0 (2 Reviews)
3 Bedrooms 6 Guests

About Sikeston Vacation Rentals

There are more than 182 places to stay in Sikeston that are available. These options include hotels, resorts, rentals as well as short-term private accommodations (i.e. RVs, Condos, Cabins, Chalets, etc.). The places can provide you with a great option on your next holiday. Compare many places to stay in Sikeston.

Are you seeking a last-minute hotel deal, or are you wanting to find the best deals available for hotels, resorts, cottages, condos, private villas, chalets, or a large vacation homes? With Hotala Sikeston, you can quickly compare different options to find the hottest deals with a single click. Looking for a resort with an infinity pool, hot tub, is pet-friendly, or features a large master suite bedrooms or has a fireplace? You can find hotels, resorts, or other popular Airbnb-style properties in or near Sikeston. Places to stay near Sikeston are 450.6 ft² on average, with prices averaging AU $215 a night.

Hotala makes it easy to find and compare hotels, resorts, and holiday rentals in Sikeston with prices often listed at a 30-40% off the rack rate. Just enter your destination and secure your reservation today.

Frequently Asked Questions About Sikeston?

What are the top hotels or resorts in Sikeston?

You have a lot of choices in or near Sikeston. If you need a hotel in the Sikeston area, consider making a reservation for a few nights at one of our suggested properties as these have been known to be the Top Vacation Rentals and Places to Stay in Sikeston:

How many hotels, resorts, or rentals are available in Sikeston?

At present, the total number of properties listed by Hotala -- including hotels, resorts, and rentals -- as of 2026 is over 182 in the Sikeston area, and still growing. By combining listings from multiple websites, Hotala provides a huge selection of the best hotels, resorts, and vacation properties in Sikeston.